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Q&A 184: differentiating BTKi from anti-CD20
Tolebrutinib is the outlier it clearly had an impact on disability worsening independent of relapses and hence on smouldering MS, which differentiates…
Sep 7
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Gavin Giovannoni
9
10
In vivo CAR T-cell therapy to treat MS
The most exciting developments in MS, is the use of engineered T-cells, or chimeric antigen receptor (CAR) T-cells, as a treatment. A new study takes…
Sep 6
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Gavin Giovannoni
22
15
3
CAR T-cell deaths in subjects with autoimmunity
As with all new technologies, when they are being transferred from oncology to autoimmunity, there may be some hurdles to overcome.
Sep 1
•
Gavin Giovannoni
10
14
1
August 2026
Familial MS risk calculator
I have produced familial risk tables from published data that you can download. As well as an online calculator to assess familial MS risk. Please let…
Aug 28
•
Gavin Giovannoni
3
27
Finding MS: health anxiety by proxy
How many of you with MS or a positive family history of MS worry about your children or grandchildren developing multiple sclerosis?
Aug 27
•
Gavin Giovannoni
8
20
1
Q&A 183 - smouldering associated worsening
Natalizumab (Tysabri) injections vs. Ublituximab (Briumvi) vs. Cladribine (Mavenclad) or Siponimod or wait for Tolebrutinib or volunteer for the…
Aug 26
•
Gavin Giovannoni
16
16
Q&A 182: hearing loss and MS
Hearing problems are quite common in people with MS; they often have problems hearing in noisy environments, i.e. following a conversation when there is…
Aug 24
•
Gavin Giovannoni
14
36
Breaking news: Checkpoint inhibitors and vaccines
Will Checkpoint inhibitors become the standard of care in therapeutic vaccine trials where T-cell exhaustion is a problem?
Aug 20
•
Gavin Giovannoni
13
13
A Miracle MS Cure, a Remote Island and a Fight for Survival: The True Story Behind the Film Eden
I recently watched Eden, a film based on the true story of a group of Europeans in the 1930’s who flee to a deserted island in hopes of creating a…
Aug 20
•
Rachel Horne
22
46
2
In defence of the term "Smouldering MS"
I, or we, my collaborators and friends, are being taken to task for adding the word smouldering MS to the medical lexicon. Apparently, nobody likes the…
Aug 18
•
Gavin Giovannoni
20
63
Q&A 181: Anti-CD20 therapies and arboviruses
I am also aware that many pwMS on immunosuppressive therapies develop infection anxiety and simply avoid high-risk travel. Does this apply to you?
Aug 17
•
Gavin Giovannoni
12
15
Is the NHS working for you?
The slow and fragmented digitisation of the NHS has direct, profound implications for patient care.
Aug 7
•
Gavin Giovannoni
11
37
1
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