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Is rituximab really superior to cladribine as a treatment for MS?
It is important to debunk this analysis of rituximab vs. cladribine because both agents are on the WHO’s essential medicine list (EML) as treatments for…
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Gavin Giovannoni
18
How to avoid a DMT cul-de-sac?
You should try to push back from being labelled as having SPMS or PPMS to prevent limiting your treatment options.
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Gavin Giovannoni
43
Q&A 99: treatment sequencing
An anti-CD20 therapy or cladribine? Or should I wait for tolebrutinib to become available?
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Gavin Giovannoni
62
Q&A 98: male sexual dysfunction in MS
Sexual dysfunction is a common symptom in men with MS, with a prevalence that surpasses that seen in the general population and other chronic disease…
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Gavin Giovannoni
4

June 2025

Gamechangers
I predict that cheap generic oral cladribine, fenebrutinib, prophylactic EBV vaccines and antiviral treatments for acute EBV-associated infectious…
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Gavin Giovannoni
54
O Canada
When you get away from the toads, you have time to test new ideas and revisit old ideas and concepts with a critical audience.
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Gavin Giovannoni
28
16:51
Q&A 97: Chemobrain?
The chemotherapy you had for your ovarian cancer (cisplatin and taxol) are neurotoxic and are likely to have contributed to your worsening function.
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Gavin Giovannoni
16
Q&A 96: skin rejuvenation therapy and MS
Is it safe for someone with MS to have polynucleotide skin injections and radio frequency, ultrasound and micro-needling therapy for skin rejuvenation?
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Gavin Giovannoni
10
Q&A 95: I live in Scotland should I have AHSCT done privately?
Almost all the cases of MS treated with AHSCT in the UK as being performed in London and Sheffield, the epicentres of AHSCT MS treatment.
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Gavin Giovannoni
23
Q&A 94: rebound on switching from fingolimod to cladribine
I don’t think cladribine has failed you. Sadly, your relapse occurred in a window before cladribine had a chance to work. This was preventable.
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Gavin Giovannoni
16
Type 1 diabetes prevention: lessons for MS
As a thought experiment would you trade in MS for having T1DM or would you stick with the autoimmune disease you know already?
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Gavin Giovannoni
25
An NHS in crisis
The UK public requires a new deal with the NHS, becoming a safety net and not necessarily the sole healthcare provider for its citizens.
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Gavin Giovannoni
40
© 2025 Gavin Giovannoni
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