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Q&A 96: skin rejuvenation therapy and MS
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Q&A 96: skin rejuvenation therapy and MS

Is it safe for someone with MS to have polynucleotide skin injections and radio frequency, ultrasound and micro-needling therapy for skin rejuvenation?

Gavin Giovannoni's avatar
Gavin Giovannoni
Jun 18, 2025
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Q&A 96: skin rejuvenation therapy and MS
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Query

I went to my dermatologist for my usual 6-monthly face and neck botox. I asked her for recommendations to freshen/regenerate my skin before a social event I have to attend this summer. She recommended three treatments:

1. Polynucleotides are injectables made from fish DNA (salmon/trout sperm) that stimulate the body's natural repair process. I am confused about whether or not I should proceed. Some say those with autoimmune conditions should not have it, as it is a foreign substance and may exacerbate them; others say there is no problem.

2. Exion Face applicator - uses radio frequency and ultrasound - no needles

3. Exion Fractional RF - uses micro needling and radio frequency procedure

The dermatologist asked me to check with my neurologist to see if I should have these treatments. I am currently on ocrelizumab, and my next Ocrevus infusion is in mid-July.

Thanks

A concerned woman with MS

NOTE: General Substack newsletters and the microsite are free; only Q&A sessions are restricted to paying subscribers. I can't run and maintain the MS-Selfie microsite, so I must pay people to help me do the work. If people want to ask medical questions unrelated to the Newsletters or Podcasts, they either need to become paying subscribers or email (ms-selfie@giovannoni.net) to request a complimentary subscription.

Prof G’s answers

These are questions I have never been asked before, but need some consideration. Please note this is not my specialist area.

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