MS-Selfie

MS-Selfie

Home
Notes
MS-Selfie Research
MS-Selfie Microsite
Contact
Q&A
Archive
Leaderboard
About
Case study: gaslit for mentioning smouldering MS
Listen now (13 mins) | My neurologist refuses to do additional tests to diagnose smouldering MS. Is there anything I can do to stop smouldering MS?
 • 
Gavin Giovannoni
33
Q&A 22 - smouldering MS on ocrelizumab
Listen now (16 mins) | I have put this gradual worsening down to ageing. Could it be smouldering MS? Is there anything that can be done about…
 • 
Gavin Giovannoni
21
Smouldering MS - a new trial
Listen now (10 mins) | We need your help and feedback on a new trial design for smouldering MS. Would you be interested in volunteering to participate?
 • 
Gavin Giovannoni
53
Case study: managing smouldering MS
Would switching from fingolimod to siponimod make any difference? What about all the other potential treatments for smouldering MS? What would you…
 • 
Gavin Giovannoni
7
Research: big data and smouldering MS
Listen now (9 mins) | Big data confirms smouldering MS is the dominant driver of disability worsening in MS and that age and loss of reserve is a major…
 • 
Gavin Giovannoni
34
9:00
Smouldering MS: the real MS becomes a tractable problem
Tolebrutinib, a second-generation BTK inhibitor, is the first to show a reduction in disability accumulation in non-relapsing secondary progressive MS…
 • 
Gavin Giovannoni
83
Q&A 65 - cladribine and smouldering MS
Cladribine impacts smouldering MS biology and is the main reason we are testing cladribine in more advanced MS to see its effect on upper limb function.
 • 
Gavin Giovannoni
31
MS-Selfie Q&A 12
Do all people with MS have smouldering disease? Do anti-CD20 therapies stop smouldering MS? I have smouldering MS on ocrelizumab; what should I do?
 • 
Gavin Giovannoni
33
Q&A 59: Will tolebrutinib change the willingness of neurologists to diagnose smouldering MS?
He told me to forget about smouldering MS and that I also don’t have secondary progressive MS. He told me to carry on as best I can. Am I going mad?
 • 
Gavin Giovannoni
32
Q&A 45 - Not to treat MS and smouldering MS
Do you agree with the decision of the two British Olympians and track stars, Lina and Laviai Nielsen, not to take disease-modifying therapies for their…
 • 
Gavin Giovannoni
40
Case study: smouldering MS - to switch or not to switch to siponimod
This patient is NEDA-2 (no relapses or MRI activity), but is getting worse on DMF (Tecfidera). She has smouldering MS. Do I label her as having SPMS and…
 • 
Gavin Giovannoni
7
Q&A 75: Natalizumab to tolebrutinib switch
Listen now (15 mins) | If you have smouldering MS would you want to switch to tolebrutinib? If you were on natalizumab with evidence of smouldering MS…
 • 
Gavin Giovannoni
19
© 2025 Gavin Giovannoni
Privacy ∙ Terms ∙ Collection notice
Start writingGet the app
Substack is the home for great culture