MS-Selfie Q&A 12

Do all people with MS have smouldering disease? Do anti-CD20 therapies stop smouldering MS? I have smouldering MS on ocrelizumab; what should I do?

Questions

Q1: Prof G, do all people with MS have smouldering disease? And does early anti-CD20 therapy stop smouldering pathology? I have been on ocrelizumab for close to 4 years, and I am getting worse. My memory is worse, I can’t walk as far, I have sexual problems, and my fatigue is preventing me from working. What would you recommend I do? 

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Answers

This is such an important question I have limited this week’s Q&A to one question, which I have expanded to three questions.

Q1a: Do all people with MS have smouldering disease? 

Q1b: Does early anti-CD20 therapy stop smouldering pathology? 

Q1c: I have been on ocrelizumab for close to 4 years, and I am getting worse. My memory is worse, I can’t walk as far, I have sexual problems, and my fatigue is preventing me from working. What would you recommend I do?