Questions
Q1: In your view, is primary progressive MS (PPMS) a smouldering disease from the start? Is it a pure smouldering MS?
Q2: Is the pathophysiology of PPMS the same or similar to non-relapsing secondary progressive MS?
Q3: Why is there a predilection towards spinal cord involvement in PPMS?
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Answer
Much dogma concerning PPMS has crept into the field and become entrenched. There is a need to challenge the dogma, in particular, the assumption that (1) PPMS is non-inflammatory, (2) people with PPMS don’t have relapses, and (3) PPMS is a different disease to relapse-onset MS. In this MS-Selfie podcast and newsletter, I challenge the dogma ……Â
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