I was on Mitoxantrone about 15 or so years ago due to very active MS and was also in my late twenties. After, as maintenance, was put on Copaxone, then Avonex (due to issues with injection sites). Am now on DMF. I have to say, although risky, Mitox immediately brought my relapses under control and have been pretty stable since but it was definitely a hard drug to be on - unfortunately, it was my only choice at the time (was waiting for Natalizumab to be licensed) and felt my MS was just too active to wait as my relapses were disabling me! So, in answer to the question, yes I do think there is a place for using Mitoxantrone where there isn't another option, such as in resource poor settings. It is important to weigh up however against these types of treatments the risks and benefits of doing so and remember that MS, when out of control, can also affect someone's life.
I was on Mitoxantrone about 15 or so years ago due to very active MS and was also in my late twenties. After, as maintenance, was put on Copaxone, then Avonex (due to issues with injection sites). Am now on DMF. I have to say, although risky, Mitox immediately brought my relapses under control and have been pretty stable since but it was definitely a hard drug to be on - unfortunately, it was my only choice at the time (was waiting for Natalizumab to be licensed) and felt my MS was just too active to wait as my relapses were disabling me! So, in answer to the question, yes I do think there is a place for using Mitoxantrone where there isn't another option, such as in resource poor settings. It is important to weigh up however against these types of treatments the risks and benefits of doing so and remember that MS, when out of control, can also affect someone's life.