Using the military analogy, it is like brainwashing your T-cells to become assassins, with only one mission to go around your body and kill all B-cells.
To others who may not know Prof G as well as I do - I have been his patient for more than 10 years now and been reading his blog(s) and papers religiously: Now G had the guts to switch me to Natalizumab at a time when 2 other consultants in 2 different trusts would not (pre-PML risk profiling) and switched me to Alemtuzumab last year when a professor and national guidelines drafter refused to do so.
He is cautiously adventurous. If he says a treatment is risky, it is very risky. Please tread with a lot of caution.
Infected b cells in the CNS are probably harder to catch. How about combining T cell therapy with anti cd 20. Let them soldiers concentrate on the CNS?
Could Autologous be preferred over allogeneic t cells. The ATA188 embold study results kinda crushed our dreams a bit.
I was wondering how you think this will compare to AHSCT?
Am I correct in assuming that the autoreactive T-cells will remain in circulation and is that significant? Also I assume it is impossible to clear EBV as it will remain in the epithelial cells, so in that respect is it similar to AHSCT (in terms of B cell depletion), where the hope is that it doesn't reactivate/trigger MS? I guess it may be possible to use CAR T-cells to kill the plasma cells in the CNS which AHSCT won't achieve.
This is seriously exciting science! I have very closely witnessed the amazingness of CAR-T therapy for cancer patients….to think that it might impact MS at some point in my lifetime with MS is humbling and super intriguing.
Sep 18, 2022·edited Sep 18, 2022Liked by Gavin Giovannoni
Any thoughts if this is an option for PPMS? AHSCT increasingly does not look like it is and OCR was never great.... Also, are you aware of anyone in Europe working on this? For a number of reasons (logistics among them), I am not keen on trials in the US (otherwise I would probably try to get into the ATA188 trial)...
Is ata 188 a car T cell treatment? And yes study sd be done!! Sadly for me I now have perm. Disability. Even after cladribine I'm still progressing.though slower I think. I'm back on glatiramer which helps me w symptoms and hopefully stops my progression.
'Would you be interested in being treated with anti-CD19 CAR T cells as part of a clinical trial?'
I'm one of your MS patients, and I'd be willing to take part, if a trial is ever done I can access. I'm just starting to realise I won't be put forward for trials, and am trying to get into a couple myself.
I would be interested in being treated with car T cells if this is something even long term MSlers might have an improvement chance with…
I would love to learn more. Let's leave the money question on the side for now. What kind of risks are we talking about here?
To others who may not know Prof G as well as I do - I have been his patient for more than 10 years now and been reading his blog(s) and papers religiously: Now G had the guts to switch me to Natalizumab at a time when 2 other consultants in 2 different trusts would not (pre-PML risk profiling) and switched me to Alemtuzumab last year when a professor and national guidelines drafter refused to do so.
He is cautiously adventurous. If he says a treatment is risky, it is very risky. Please tread with a lot of caution.
I have had SLE for over 20 years and is moderately controlled by plaquenil. Do think this can also help with Ms?
I am in the US, 54 years old, maybe PPMS, and interested to learn more about the trial.
Patfeller14@gmail.com
Thank you Dr. G!
Infected b cells in the CNS are probably harder to catch. How about combining T cell therapy with anti cd 20. Let them soldiers concentrate on the CNS?
Could Autologous be preferred over allogeneic t cells. The ATA188 embold study results kinda crushed our dreams a bit.
Hi, where can come in contact with you? I want to try the CAR-T-Cells method for MS, my email: Rensteeuwen@outlook.com
Hi I can you email me the info for the clinical trial at jkuhn8989@yahoo.com
Thanks!
Hi can you email me the info for the clinical trial to jkuhn8989@yahoo.com Thanks!
Many thanks for the information Prof G.
I was wondering how you think this will compare to AHSCT?
Am I correct in assuming that the autoreactive T-cells will remain in circulation and is that significant? Also I assume it is impossible to clear EBV as it will remain in the epithelial cells, so in that respect is it similar to AHSCT (in terms of B cell depletion), where the hope is that it doesn't reactivate/trigger MS? I guess it may be possible to use CAR T-cells to kill the plasma cells in the CNS which AHSCT won't achieve.
Hi,
I tried Ocrevus, and ended up having a flare-up of MS, as my B cells were depleted, would this occur if I tried CAR T-cell? Thank you! Nina
This is seriously exciting science! I have very closely witnessed the amazingness of CAR-T therapy for cancer patients….to think that it might impact MS at some point in my lifetime with MS is humbling and super intriguing.
Any thoughts if this is an option for PPMS? AHSCT increasingly does not look like it is and OCR was never great.... Also, are you aware of anyone in Europe working on this? For a number of reasons (logistics among them), I am not keen on trials in the US (otherwise I would probably try to get into the ATA188 trial)...
Do CAR T-cells fight and target EBV?
Is ata 188 a car T cell treatment? And yes study sd be done!! Sadly for me I now have perm. Disability. Even after cladribine I'm still progressing.though slower I think. I'm back on glatiramer which helps me w symptoms and hopefully stops my progression.
'Would you be interested in being treated with anti-CD19 CAR T cells as part of a clinical trial?'
I'm one of your MS patients, and I'd be willing to take part, if a trial is ever done I can access. I'm just starting to realise I won't be put forward for trials, and am trying to get into a couple myself.