8 Comments
Jun 19, 2022Liked by Gavin Giovannoni

Just saw this in my emails. I have this response to gabapentin. My legs “disappear”. I gather it’s an old epilepsy med and this is the explanation?

Expand full comment
author

Yes, that is correct. Gabapentin is now more commonly used to treat central pain syndromes and spasticity than an anti-convulsant.

Expand full comment
Jan 29, 2022Liked by Gavin Giovannoni

thanks prof g. the power suit with motorised muscles, it sure is a cool invention. although not very affordable i've read users say its life changing being upright again and perhaps would have some knock on benefits physiologically from moving the whole body again.

Expand full comment
Jan 29, 2022·edited Jan 29, 2022Liked by Gavin Giovannoni

Ty again dr G. Hopefully, the new remyelination drugs will make us strong again. NVG291, Ata 188 et al.

BTW, gilenya caused me afib. Rob

Expand full comment
Jan 29, 2022Liked by Gavin Giovannoni

very interesting.

Expand full comment
founding
Jan 29, 2022Liked by Gavin Giovannoni

How's the trade off between neuroprotection and side effects of sodium channel blockers for less advanced PwMS?

Expand full comment
author

Yes, people early in their course of their disease with low disability tolerate sodium channel blockers better. This is what we saw in the PROXIMUS trial.

Expand full comment

Thanks a lot for sharing

Expand full comment