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Q&A 62: MS and comorbid inflammatory bowel disease
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Q&A 62: MS and comorbid inflammatory bowel disease

Does anti-CD20 therapies make inflammatory bowel disease (IBD) worse? Do anti-CD20 therapies cause IBD? How to treat MS in someone with IBD.

Case study

I was diagnosed with relapsing-remitting MS two months ago; I also have Crohn's. I was told I would usually be offered ocrelizumab (Ocrevus), but due to my Crohn's, I have only been provided a mid-efficacy DMT. I have unhappily agreed to dimethyl fumarate (Tecfidera). I asked for natalizumab (Tysrabi) but was told I did not meet the NICE criteria. I have an aunt who has been a wheelchair user for the last 20 years due to a bad relapse. I want to argue my case for a higher-efficacy DMT. My GP and gastro have agreed with me and are willing to write supportive letters. Can you give me any advice on what else I can do? Everything I have read says a high-efficacy DMT from diagnosis is the best treatment.

IBD

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Prof G’s answer

Yes, but ……

Should ublituximab be prioritised over ocrelizumab and ofatumumab as a treatment for MS? …..

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Gavin Giovannoni