I have been thinking about this for years. Since the US military study on EVB and MS, I have been looking for a trial. My 16 year old daughter actually is in one of the trials right now. She was negative in the screening so we thought it was worth a try to lower her MS risk.
Could this be flipped by studying people who for some reason have not contracted EBV as this is a much smaller cohort? Study their rates and types of inflammatory disease compared to the general population etc
Perhaps this could for instance uncover a gene therapy solution?
I think you are such a healthy man that you could see MS cured/prevented from other directions (i.e. other than EBV), if EBV related research ended up being a dead-end :)
I had an invasive melanoma diagnosed and treated two years ago. There are no Mets, but who knows what is waiting around the corner? Similarly, four years ago, I had a significant accident with polytrauma, including a fractured C-spine. I am lucky not to be a paraplegic. So, I am taking nothing for granted.
I'm a great supporter of vaccines and EBV is clearly an essential risk factor in MS and other auto-immune disorders as well as cancers. But most people live long lives without getting these illnesses. Shouldn't there be a focus on these people? How are their lives different to those who become ill? I have been reading Gabor Mate recently, who believes that trauma plays a major part in these illnesses.
Not sure what you mean. Yes, many people live long lives without getting these illnesses, but this is how we determine risk factors for getting diseases by using these people as controls. The good news is the majority of people with a poor risk profile don't get MS. I suspect lousy luck plays a role in people who get these diseases. Trying to prevent bad luck from playing a role is to avoid them from getting infected with EBV and/or developing IM.
Interesting listen. I guess we will all have to 'Watch and Wait' as I have heard many times from Neurologists. Big Parma will be keen to crack on with it if it is lucrative. I would prefer not to take a vaccine until I feel comfortable to do so. Xx
I have been thinking about this for years. Since the US military study on EVB and MS, I have been looking for a trial. My 16 year old daughter actually is in one of the trials right now. She was negative in the screening so we thought it was worth a try to lower her MS risk.
Could this be flipped by studying people who for some reason have not contracted EBV as this is a much smaller cohort? Study their rates and types of inflammatory disease compared to the general population etc
Perhaps this could for instance uncover a gene therapy solution?
That is what we want to do, but finding them is difficult.
I think you are such a healthy man that you could see MS cured/prevented from other directions (i.e. other than EBV), if EBV related research ended up being a dead-end :)
I had an invasive melanoma diagnosed and treated two years ago. There are no Mets, but who knows what is waiting around the corner? Similarly, four years ago, I had a significant accident with polytrauma, including a fractured C-spine. I am lucky not to be a paraplegic. So, I am taking nothing for granted.
I'm a great supporter of vaccines and EBV is clearly an essential risk factor in MS and other auto-immune disorders as well as cancers. But most people live long lives without getting these illnesses. Shouldn't there be a focus on these people? How are their lives different to those who become ill? I have been reading Gabor Mate recently, who believes that trauma plays a major part in these illnesses.
Re: "Gabor Mate recently, who believes that trauma plays a major part in these illnesses"
Yes and no. Trauma only explains a tiny proportion of MS risk.
Not sure what you mean. Yes, many people live long lives without getting these illnesses, but this is how we determine risk factors for getting diseases by using these people as controls. The good news is the majority of people with a poor risk profile don't get MS. I suspect lousy luck plays a role in people who get these diseases. Trying to prevent bad luck from playing a role is to avoid them from getting infected with EBV and/or developing IM.
Interesting listen. I guess we will all have to 'Watch and Wait' as I have heard many times from Neurologists. Big Parma will be keen to crack on with it if it is lucrative. I would prefer not to take a vaccine until I feel comfortable to do so. Xx