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SammyJo Wilkinson's avatar

Excellent explanation to start more experiments to zero in on EBV in MS.

ACTRIMS2023 Just concluded and had a strong focus on EBV and MS. Steven Jacobson @NIH presented a slide with Rx contenders for EBV. Don't yet know what he said but in the Antiviral category he listed: Brincidofovir, Raltegravir, Tenofovir, Valacyclovir, Interferons.

Antiretrovirals (TAF, TDF) have published case studies showing multi-year MS NEDA. Followed by cell-assay studies showing TAF most effective (Druso 2020)

But Brincidofovir was the one he put a circle around.

Slide snapshot: https://twitter.com/drbarrysinger/status/1629178462945820673

Brincidofovir is a broad antiviral against several DNA viruses, including HHV-6 and EBV for which it has a high EC50 of 10. But would it have any effect on latent EBV or only reactivated?

The antivirals are attractive b/c they are already FDA approved and if effective could help mitigate MS damage, while the vaccines and other therapies go through the long process to approval.

Which antivirals do you think should go into human biomarker trials like you did for Famvir?

Would concurrent animal model testing be helpful? Studies of EBV in a humanized mouse model and rabbit have been published.

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Anna's avatar

Are there not enough of us from a significant number of countries that we translate this letter and attach it in an open letter to our national ms societies asking them to please print it on their website?

Sure to create some publicity to raise money to do haart?

Or am i way off with fhis..

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