MS-Selfie Live Q&A
At 17h00 GMT, I will launch a live Q&A session for paying subscribers using the Substack live feed.
I am trying something new today. At 17h00 GMT, I will launch a live Q&A session for paying subscribers using the Substack live feed. The platform will send you an email with a link. I plan to cover the following questions:
What are Prof G’s MS research highlights from 2024?
What are Prof G’s predictions for 2025 concerning MS research and treatments?
What exercise protocols would you advise people with MS to attempt?
If you have any other questions you would like me to address, please leave them in the comments section. I want these sessions to last no more than 30 minutes, about double the attention span of the average person consuming web content. As I plan to do these weekly, we can always carry over questions to the next session.
If you can’t attend the live session, I will post the recording for you to watch and/or listen to later.
NOTE: General substack newsletters and the microsite are free; only Q&A sessions are restricted to paying subscribers. I can't run and maintain the MS-Selfie microsite, so I must pay people to help me do the work. If people want to ask medical questions unrelated to the Newsletters or Podcasts, they either need to become paying subscribers or email (ms-selfie@giovannoni.net) to request a complimentary subscription.
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General Disclaimer
Please note that the opinions expressed here are those of Professor Giovannoni and do not necessarily reflect the positions of Queen Mary University of London or Barts Health NHS Trust. The advice is intended as general and should not be interpreted as personal clinical advice. If you have problems, please tell your healthcare professional, who will be able to help you.
I have been diagnosed for 12 years now and am 65 years of age.
I have taken a number of DMTs over that time including Tecfidera, Gilenya and Tysabri. Tysabri worked well until I was JCV positive and then I decided to switch to Cladribine. I have now finished my 2 year course of treatment and lymphocyte levels are now back within normal range. Brain MRI's have been stable for a long time since my last relapse back in 2017, which happened after withdrawal from Gilenya therapy. This relapse left me with weakness and numbness in my left leg and some mild mobility problems.
Since then balance, cognition and motor coordination have more recently started to worsen and mild levels of similar symptoms have been noticed in my right leg.
Are these changes a sign of smoldering MS and if so is there anything that might help slow down any disease progression?
Could this increase in symptoms be due to reconstitution of my immune system post treatment?
As I am considered to be doing well by my neurology team they don't seem to be concerned that I am experiencing symptom worsening.
Thanks,
Judith
Amazing thanks Prof G
Can you summarise any pivotal studies that are due to deliver results in the next year or so?